Phenotypes associated with this allele

• Allele Symbol: Hmga2^em1Hokl
• Allele Name: endonuclease-mediated mutation 1, Sabine Hombach-Klonisch
• Allele ID: MGI:8282794
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmga2^em1Hokl/Hmga2^em1Hokl	C57BL/6J-Hmga2^em1Hokl	MGI:8283260
ht2	Hmga2^em1Hokl/Hmga2^+	C57BL/6J-Hmga2^em1Hokl	MGI:8283261

Genotype
MGI:8283260

hm1

• Allelic Composition: Hmga2^em1Hokl/Hmga2^em1Hokl
• Genetic Background: C57BL/6J-Hmga2^em1Hokl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

abnormal facial morphology ( J:348065 )

• occasionally, dwarfism is associated with dysmorphic facial features and mainly seen in young mice

decreased body size ( J:348065 )

decreased body weight ( J:348065 )

prenatal growth retardation ( J:348065 )

• small for gestation size

craniofacial

abnormal facial morphology ( J:348065 )

• occasionally, dwarfism is associated with dysmorphic facial features and mainly seen in young mice

adipose tissue

abnormal fat cell differentiation ( J:348065 )

• mouse embryonic fibroblasts (MEFs) show diminished adipogenic differentiation, with reduced lipid droplet formation

cellular

abnormal fat cell differentiation ( J:348065 )

• mouse embryonic fibroblasts (MEFs) show diminished adipogenic differentiation, with reduced lipid droplet formation

reproductive system

reproductive system phenotype ( J:348065 )

N • mice are fertile

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Silver-Russell syndrome		DOID:14681	OMIM:180860	J:348065

Genotype
MGI:8283261

ht2

• Allelic Composition: Hmga2^em1Hokl/Hmga2⁺
• Genetic Background: C57BL/6J-Hmga2^em1Hokl

growth/size/body

growth/size/body region phenotype ( J:348065 )

N • mice are not growth restricted