Phenotypes associated with this allele

• Allele Symbol: Ptms^em1Caid
• Allele Name: endonuclease-mediated mutation 1, Dongsheng Cai
• Allele ID: MGI:8275781
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptms^em1Caid/Ptms^em1Caid	involves: C57BL/6J	MGI:8275782

Genotype
MGI:8275782

hm1

• Allelic Composition: Ptms^em1Caid/Ptms^em1Caid
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:376331 )

• significantly shorter lifespan

nervous system

brain atrophy ( J:376331 )

• pronounced atrophy in multiple regions in aged mice

neurodegeneration ( J:376331 )

• biomarker analysis detects neurodegeneration in multiple brain regions in middle-aged mice

behavior/neurological

abnormal behavior ( J:376331 )

• behavioral abnormalities are seen in old but not young mice and deficits become more severe with age

impaired spatial learning ( J:376331 )

• in aged but not young mice

decreased grip strength ( J:376331 )

• in aged but not young mice