All Phenotypes Elp6<em1Bjw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elp6^em1Bjw
endonuclease-mediated mutation 1, Brandon J Wainwright
MGI:8275247

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elp6^em1Bjw/Elp6^em1Bjw	C57BL/6-Elp6^em1Bjw	MGI:8275320
ht2	Elp6^em1Bjw/Elp6⁺	Not Specified	MGI:8275322

Allelic Composition	Elp6^em1Bjw/Elp6^em1Bjw
Genetic Background	C57BL/6-Elp6^em1Bjw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elp6^em1Bjw mutation (0 available); any Elp6 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:360936 )

• hindlimb clasping

tremors ( J:360936 )

ataxia ( J:360936 )

impaired balance ( J:360936 )

impaired limb coordination ( J:360936 )

increased locomotor activity ( J:360936 )

• increased spontaneous activity

growth/size/body

growth/size/body region phenotype ( J:360936 )

N	• no microcephaly or developmental delay

slow postnatal weight gain ( J:360936 )

• owing to reduced feeding ability as a result of motor defects

mortality/aging

premature death ( J:360936 )

• death before age 9 months

muscle

muscle weakness ( J:360936 )

nervous system

nervous system phenotype ( J:360936 )

N	• normal interneurons and myelin in forebrain at age 60 days • no microcephaly

abnormal hippocampal pyramidal neuron dendrite morphology ( J:360936 )

• shorter length and less branching at age 60 days

• normal dendritic spine density

abnormal excitatory postsynaptic potential ( J:360936 )

• reduced field excitatory postsynaptic potential (fEPSP) after applying high-frequency stimulation (HFS) to trigger long-term potentiation (LTP) at Schaffer collateral to CA1 pyramidal neuron synapse at age 60 days

Allelic Composition	Elp6^em1Bjw/Elp6⁺
Genetic Background	Not Specified