Phenotypes associated with this allele

• Allele Symbol: Mfn2^em1Dabsa
• Allele Name: endonuclease-mediated mutation 1, David B Savage
• Allele ID: MGI:8272328
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfn2^em1Dabsa/Mfn2^em1Dabsa	C57BL/6J-Mfn2^em1Dabsa	MGI:8273424

Genotype
MGI:8273424

hm1

• Allelic Composition: Mfn2^em1Dabsa/Mfn2^em1Dabsa
• Genetic Background: C57BL/6J-Mfn2^em1Dabsa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:376364 )

♂N • normal adipose depot mass when fed normal chow or HFD

♂N • normal hepatic steatosis and lipid droplet size in BAT and WAT when fed normal chow or HFD

abnormal fat cell mitochondrial morphology ( J:376364 )

• smaller fragmented mitochondria and disrupted cristae in BAT and inguinal and epidydimal WAT

decreased fat cell mitochondrial DNA content ( J:376364 )

• in BAT

• normal in inguinal and epidydimal WAT

cellular

cellular phenotype ( J:376364 )

N • normal thermogenic capacity in cold temperatures

N • normal mitochondrial oxidative phosphorylation in BAT and liver

abnormal mitochondrial morphology ( J:376364 )

• smaller fragmented mitochondria and disrupted cristae in BAT and inguinal and epidydimal WAT

• decreased MT DNA content in BAT

• normal in heart, skeletal muscle and liver

abnormal fat cell mitochondrial morphology ( J:376364 )

• smaller fragmented mitochondria and disrupted cristae in BAT and inguinal and epidydimal WAT

decreased fat cell mitochondrial DNA content ( J:376364 )

• in BAT

• normal in inguinal and epidydimal WAT

disorganized mitochondrial cristae ( J:376364 )

• in BAT and inguinal and epidydimal WAT

• normal in heart, skeletal muscle and liver

decreased mitochondrial size ( J:376364 )

• in BAT and inguinal and epidydimal WAT

growth/size/body

growth/size/body region phenotype ( J:376364 )

N • normal body mass and composition when fed normal chow or HFD

N • normal adipose depot and other organ masses when fed normal chow or HFD

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:376364 )

N • normal glucose and insulin tolerance when fed normal chow or HFD

decreased circulating leptin level ( J:376364 )

• when fed normal chow or HFD

decreased circulating adiponectin level ( J:376364 )

• when fed normal chow or HFD

liver/biliary system

liver/biliary system phenotype ( J:376364 )

♂N • normal hepatic steatosis when fed normal chow or HFD