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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kif5aem1Kolb
endonuclease-mediated mutation 1, Stephen J Kolb
MGI:8270893
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kif5aem1Kolb/Kif5aem1Kolb C57BL/6-Kif5aem1Kolb MGI:8270931


Genotype
MGI:8270931
hm1
Allelic
Composition		 Kif5aem1Kolb/Kif5aem1Kolb
Genetic
Background		 C57BL/6-Kif5aem1Kolb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif5aem1Kolb mutation (0 available); any Kif5a mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to nerve crush injury ( J:374864 )
• impaired motor unit sciatic nerve crush recovery: delayed and incomplete
• decreased ipsilateral motor neuron area 16 weeks after injury at age 14 weeks and after injury at age 35 weeks
• decreased ipsilateral sciatic nerve fiber and axon diameter area 16 weeks after injury at age 14 weeks
• decreased pre- and postsynaptic NMJ recovery 16 weeks after injury at age 14 weeks and after injury at age 35 weeks
• decreased motor unit repair after injury at age 35 weeks
• normal grip strength in injured and uninjured hindlimbs 16 weeks after injury at age 14 weeks
• normal number of sciatic nerve fibers distal to injury site 16 weeks after injury at age 14 weeks
• no cellular aggregations in lumbar motor neurons after injury

nervous system
increased susceptibility to nerve crush injury ( J:374864 )
• impaired motor unit sciatic nerve crush recovery: delayed and incomplete
• decreased ipsilateral motor neuron area 16 weeks after injury at age 14 weeks and after injury at age 35 weeks
• decreased ipsilateral sciatic nerve fiber and axon diameter area 16 weeks after injury at age 14 weeks
• decreased pre- and postsynaptic NMJ recovery 16 weeks after injury at age 14 weeks and after injury at age 35 weeks
• decreased motor unit repair after injury at age 35 weeks
• normal grip strength in injured and uninjured hindlimbs 16 weeks after injury at age 14 weeks
• normal number of sciatic nerve fibers distal to injury site 16 weeks after injury at age 14 weeks
• no cellular aggregations in lumbar motor neurons after injury




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory