Phenotypes associated with this allele

• Allele Symbol: Dmd^em2Rcn
• Allele Name: endonuclease-mediated mutation 2, Ronald D Cohn
• Allele ID: MGI:8270634
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Dmd^em2Rcn/Y	C57BL/6J-Dmd^em2Rcn	MGI:8270929

Genotype
MGI:8270929

ot1

• Allelic Composition: Dmd^em2Rcn/Y
• Genetic Background: C57BL/6J-Dmd^em2Rcn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:376007 )

♂N • 12-week-old mice show normal muscle histology, normal muscle function, and exercise-induced damage

impaired skeletal muscle contractility ( J:376007 )

♂ • 52-week-old mice show a decrease in contractile force at 75, 100, and 125 Hz after exercise

increased muscle fatigability ( J:376007 )

♂ • 52-week-old, but not 12-week-old, exercised mice show reduced forelimb grip strength and contractile force indicating a fatigued phenotype

cardiovascular system

cardiovascular system phenotype ( J:376007 )

♂N • mice exhibit normal heart rate throughout 12 to 52 weeks of age, with normal ejection fraction and fractional shortening

abnormal heart echocardiography feature ( J:376007 )

♂ • a small, but significant, increase in posterior wall thickness during diastole is seen at 12 weeks of age and a decrease in end diastolic diameter is seen at 28 weeks of age

♂ • however, mice show normal echocardiography, with similar posterior wall thickness during systole, systolic volume, diastolic volume and end systolic diameter, throughout 12-52 weeks of age

homeostasis/metabolism

abnormal response to exercise ( J:376007 )

♂ • forelimb grip strength after exercise is lower at 52 weeks of age but not at 12 weeks of age

♂ • 52-week-old mice show a decrease in contractile force at 75, 100, and 125 Hz after exercise

♂ • however, performances in open-field parameters are similar to wild-type mice pre- and post-exercise

behavior/neurological

decreased grip strength ( J:376007 )

♂ • forelimb grip strength after exercise is lower at 52 weeks of age but not at 12 weeks of age

growth/size/body

growth/size/body region phenotype ( J:376007 )

♂N • 12-week-old mice show normal weight

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Becker muscular dystrophy		DOID:9883	OMIM:300376	J:376007