Analysis Tools
behavior/neurological
| N |
• mice show no deficits in memory in the spontaneous alternation, novel object recognition, Morris water maze, and contextual fear conditioning, and no differences in activity in the open field test
|
 |
• in the elevated plus maze, 9-week-old males spend more time than females in the open arms while no differences are seen between wild-type females and males, exhibit a reduced duration in the proximal open arm compared to females and wild-type males, and spend more time in the distal arm compared to females or wild-type males, indicating that males exhibit lower anxiety-like behavior and potentially higher risk-taking compared to females or alternatively, males have a stronger drive to spontaneous exploratory behavior
|
nervous system
|
• primary hippocampal neurons from P1-P3 female mice show a reduction in tertiary branches and mild reduction in distal secondary branches, and no differences in proximal secondary branches
• primary hippocampal neurons from P1-P3 male mice show a reduction in branching uniformly in the secondary as well tertiary branching
• however, P14 mice do not exhibit changes in dendritic arborization, length, or spine density, or in the number of dendritic branch points and no changes are seen at P42
|
|
• primary hippocampal neurons from P1-P3 female and male mice show a reduction in total spines but no differences are seen between males and females
|
 |
• primary hippocampal neurons from P1-P3 females show an increase in thin spines, while males show no differences in mushroom, thin, or stubby spines
|
