Phenotypes associated with this allele

• Allele Symbol: Gm38257^em1Svpu
• Allele Name: endonuclease-mediated mutation 1, Sathyanarayanan V Puthanveettil
• Allele ID: MGI:8263065
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gm38257^em1Svpu/Gm38257^em1Svpu	C57BL/6N-Gm38257^em1Svpu	MGI:8263068

Genotype
MGI:8263068

hm1

• Allelic Composition: Gm38257^em1Svpu/Gm38257^em1Svpu
• Genetic Background: C57BL/6N-Gm38257^em1Svpu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:370383 )

N • mice exhibit normal behavior in the elevated plus maze and show no deficits in memory in the spontaneous alternation, novel object recognition, Morris water maze, and contextual fear conditioning, or in activity in the open field test

nervous system

abnormal dendrite arborization pattern ( J:370383 )

• primary hippocampal neurons from P1-P3 male and female mice show a reduction in arborization in the distal secondary and tertiary branching

• however, P14 mice do not exhibit changes in dendritic arborization, length, or spine density, or in the number of dendritic branch points

decreased dendritic spine number ( J:370383 )

• primary hippocampal neurons from P1-P3 female and male mice show a reduction in total spines but no differences are seen between males and females

abnormal dendritic stubby spine morphology ( J:370383 )

• both males and females show a reduction in stubby spines in primary hippocampal neurons at P1-P3 and females show

abnormal dendritic thin spine morphology ( J:370383 )

♀ • P1-P3 females show an increase in thin spine type in primary hippocampal neurons compared to wild-type females and homozygous males

♀ • P42 female mice show a modest but significant reduction in thin spines resulting in a reduction in the total spine density