Analysis Tools
mortality/aging
|
• perinatal lethality due to respiratory failure, with all mice dying shortly after birth
|
respiratory system
|
• lung structure is disorganized at E18.5
• lungs have irregular surfaces and thicker alveolar walls, smaller airspaces, and more numerous small alveoli
• the distribution of type I alveolar epithelial cells, type II alveolar epithelial cells and Clara cells is disorganized in lung lobes at E18.5
|
|
• the number of F4/80-positive macrophages is increased in the lung interstitium
• however, the numbers of T cells and apoptotic cells are not increased
|
small lung
(
J:369095
)
|
• lungs are smaller in neonates
|
|
• lungs have more numerous small alveoli
|
|
• lungs sink in PBS indicating that death is due to postnatal respiratory failure
|
immune system
|
• the number of F4/80-positive macrophages is increased in the lung interstitium
|
hematopoietic system
|
• the number of F4/80-positive macrophages is increased in the lung interstitium
|
cardiovascular system
| N |
• hearts show no morphological or histological abnormalities at E18.5, with normal vascular branching, aortic arch, thoracoabdominal aorta, and pulmonary artery, no disarrangement of elastic laminae in the arterial wall, and no stenosis in the tracheal cartilage
|
growth/size/body
| N |
• neonates show no external abnormalities, with no differences in body weight, heart weight, or brain weight
|
