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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acta2tm1.1Dmmz
targeted mutation 1.1, Dianna M Milewicz
MGI:8250493
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Acta2tm1.1Dmmz/Acta2+
Tg(Tagln-cre)1Her/0 		B6.Cg-Acta2tm1.1Dmmz Tg(Tagln-cre)1Her MGI:8253396


Genotype
MGI:8253396
cn1
Allelic
Composition		 Acta2tm1.1Dmmz/Acta2+
Tg(Tagln-cre)1Her/0
Genetic
Background		 B6.Cg-Acta2tm1.1Dmmz Tg(Tagln-cre)1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acta2tm1.1Dmmz mutation (0 available); any Acta2 mutation (56 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aorta morphology ( J:369814 )
• aortas show flattened elastic lamellae, rounded appearance of the smooth muscle cells, and reduced ascending medial thickness with no changes in the number of elastin layers or cell density in the media
• however, mice do not show enlargement of the aortic root or ascending aorta up to 12 months of age
decreased systemic arterial blood pressure ( J:369814 )
• mice exhibit reduced blood pressures at 2 and 12 months of age

mortality/aging
mortality/aging ( J:369814 )
N
• sudden death is not observed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory