Phenotypes associated with this allele

• Allele Symbol: Tubb4b^em5Golab
• Allele Name: endonuclease-mediated mutation 5, Genetic in Ophtalmology Laboratory
• Allele ID: MGI:8249378
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tubb4b^em5Golab/Tubb4b^+	C57BL/6J-Tubb4b^em5Golab	MGI:8328271

Genotype
MGI:8328271

ht1

• Allelic Composition: Tubb4b^em5Golab/Tubb4b⁺
• Genetic Background: C57BL/6J-Tubb4b^em5Golab

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:360308 )

• increase in premature death

cellular

abnormal respiratory motile cilium morphology ( J:360308 )

• loss of multicilia throughout the respiratory epithelium

nervous system

hydrocephaly ( J:360308 )

• mice develop hydrocephaly neonatally

reproductive system

infertility ( J:360308 )

• male and female infertility

respiratory system

abnormal respiratory motile cilium morphology ( J:360308 )

• loss of multicilia throughout the respiratory epithelium

abnormal mucociliary clearance ( J:360308 )

• mice develop defects in mucociliary clearance within the upper airways with loss of multicilia throughout the respiratory epithelium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia		DOID:9562	OMIM:PS244400	J:360308