Phenotypes associated with this allele

• Allele Symbol: Adcy2^em1Jde
• Allele Name: endonuclease-mediated mutation 1, Jan Deussing
• Allele ID: MGI:8246800
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcy2^em1Jde/Adcy2^em1Jde	involves: C57BL/6J * C57BL/6N	MGI:8246801

Genotype
MGI:8246801

hm1

• Allelic Composition: Adcy2^em1Jde/Adcy2^em1Jde
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to amphetamine ( J:360838 )

• hypersensitive to amphetamine treatment (4 mg/kg) induced increase in locomotor activity

abnormal long-term spatial reference memory ( J:360838 )

• deficits in long term memory indicated by reduced time spent in the target quadrant of a Morris water maze at day 7

impaired learning ( J:360838 )

• slower learners in a Morris water maze

abnormal coping response ( J:360838 )

• in a forced swim test spend more time swimming and less floating

• treatment with lithium restores activity to control levels

• following 3 weeks of chronic social defeat stress mice spend more time floating and less time actively swimming

decreased anxiety-related response ( J:360838 )

• spend more time in the center of an open field and enter the inner zone more often compared to controls

• however, distance traveled is not different from controls

• spend more time in the lit zone of a dark-light box

• treatment with lithium reduces the time spent in the center of an open field

• following 3 weeks of chronic social defeat stress, entries into the inner zone and time spent in the center are reduced unlike in similarly treated controls

abnormal response to novel object ( J:360838 )

• spend more time investigating a novel object

hyperactivity ( J:360838 )

• increased activity in the first 2 dark phases in a novel environment

• however, in an open field test distance traveled is not different from controls

nervous system

increased nervous system dopamine level ( J:360838 )

• increase dopamine levels in the prefrontal cortex, striatum, nucleus accubens, and hippocampus following amphetamine treatment, compared to treatment matched controls

reduced long-term potentiation ( J:360838 )

• significant decrease in long term potentiation after high-frequency stimulation in CA3-CA1 synapses

increased miniature excitatory postsynaptic current frequency ( J:360838 )

• increase in the frequency of AMPA receptor mediated miniature excitatory postsynaptic currents in CA1 pyramidal neurons

decreased miniature inhibitory postsynaptic current frequency ( J:360838 )

• decreased frequency of GABAA receptor mediated miniature inhibitory postsynaptic currents

homeostasis/metabolism

increased nervous system dopamine level ( J:360838 )

• increase dopamine levels in the prefrontal cortex, striatum, nucleus accubens, and hippocampus following amphetamine treatment, compared to treatment matched controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
bipolar disorder		DOID:3312		J:360838