Phenotypes associated with this allele

• Allele Symbol: Sass6^em2Baz
• Allele Name: endonuclease-mediated mutation 2, Hisham Bazzi
• Allele ID: MGI:8242360
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sass6^em2Baz/Sass6^em2Baz	involves: FVB/NRj	MGI:8242372
cx2	Sass6^em2Baz/Sass6^em2Baz Tg(CAG-EGFP/CETN2)3-4Jgg/0	involves: BALB/c * C57BL/6 * FVB/NRj	MGI:8242376

Genotype
MGI:8242372

hm1

• Allelic Composition: Sass6^em2Baz/Sass6^em2Baz
• Genetic Background: involves: FVB/NRj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:347621 )

• arrest at ~E9.5 with heart formation but no somites

embryo

abnormal embryo turning ( J:347621 )

embryonic growth arrest ( J:347621 )

• arrest at ~E9.5

impaired somite development ( J:347621 )

• do not show somites at ~E9.5

cellular

abnormal microtubule organizing center morphology ( J:347621 )

• at E9.0, no centrioles are present in mitotic poles

Genotype
MGI:8242376

cx2

• Allelic Composition: Sass6^em2Baz/Sass6^em2Baz; Tg(CAG-EGFP/CETN2)3-4Jgg/0
• Genetic Background: involves: BALB/c * C57BL/6 * FVB/NRj

cellular

abnormal microtubule organizing center morphology ( J:347621 )

• very few cells from E9.0 embryos show centrioles (2% compared to 98% in wild-type embryos)

• in cultured ES cells almost half of all centrioles are abnormal, about one third have normal-like centrioles, and the rest have thread-like structures