Phenotypes associated with this allele

• Allele Symbol: Pou1f1^em1Snar
• Allele Name: endonuclease-mediated mutation 1, Satoshi Narumi
• Allele ID: MGI:8240788
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou1f1^em1Snar/Pou1f1^em1Snar	involves: C57BL/6JmsSlc * C57BL/6NCrSlc * DBA/2CrSlc	MGI:8240847

Genotype
MGI:8240847

hm1

• Allelic Composition: Pou1f1^em1Snar/Pou1f1^em1Snar
• Genetic Background: involves: C57BL/6JmsSlc * C57BL/6NCrSlc * DBA/2CrSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:369969 )

• from 3 weeks of age, mice need a warm environment with easy access to food and water in order to survive

growth/size/body

decreased body weight ( J:369969 )

• mice are normal size at 1 week of age but are approximately half the weight of wild-type mice at 3 week and the average body weight is about 35% of wild-type at 12 weeks

postnatal growth retardation ( J:369969 )

• mice normally until 2 weeks of age and show growth retardation after this point

endocrine/exocrine glands

absent somatotrophs ( J:369969 )

• growth hormone-expressing somatotroph cells are not detected in anterior lobes of the pituitary gland

decreased pituitary gland weight ( J:369969 )

• the body weight-adjusted pituitary gland weight is 40% of that of wild-type mice and the anterior lobe is particularly hypoplastic while the middle and posterior lobes are similar in size to wild-type mice

homeostasis/metabolism

decreased circulating thyroxine level ( J:369969 )

• serum levels of total thyroxine are 20% of wild-type littermates

decreased circulating prolactin level ( J:369969 )

• circulating prolactin levels are undetectable

decreased circulating insulin-like growth factor I level ( J:369969 )

• circulating IGF-1 levels are undetectable

decreased circulating adrenocorticotropin level ( J:369969 )

• circulating adrenocorticotropin levels are slightly higher than in wild-type mice, but there are large individual differences regardless of genotype or sex

nervous system

absent somatotrophs ( J:369969 )

• growth hormone-expressing somatotroph cells are not detected in anterior lobes of the pituitary gland

decreased pituitary gland weight ( J:369969 )

• the body weight-adjusted pituitary gland weight is 40% of that of wild-type mice and the anterior lobe is particularly hypoplastic while the middle and posterior lobes are similar in size to wild-type mice