Phenotypes associated with this allele

• Allele Symbol: Cdadc1^em2Jmdn
• Allele Name: endonuclease-mediated mutation 2, Javier M Di Noia
• Allele ID: MGI:8240200
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdadc1^em2Jmdn/Cdadc1^em2Jmdn	B6J.B6N-Cdadc1^em2Jmdn	MGI:8240315

Genotype
MGI:8240315

hm1

• Allelic Composition: Cdadc1^em2Jmdn/Cdadc1^em2Jmdn
• Genetic Background: B6J.B6N-Cdadc1^em2Jmdn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:368532 )

• mice are hypersensitive to gemcitabine and rapidly reach humane endpoints for euthanasia

increased physiological sensitivity to xenobiotic ( J:368532 )

• mice are hypersensitive to gemcitabine, an antimetabolite chemotherapy drug, showing more than 20% weight loss and diarrhea, thrombocytopenia and leukopenia, with highly reduced myeloid and lymphoid cells within the bone marrow and rapidly reach humane endpoints for euthanasia

• however, untreated mice exhibit no physical or health abnormalities

hematopoietic system

hematopoietic system phenotype ( J:368532 )

N • mice exhibit normal blood leukocyte populations

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:368532 )

• mice are hypersensitive to gemcitabine and rapidly reach humane endpoints for euthanasia

reproductive system

reproductive system phenotype ( J:368532 )

N • mice exhibit normal fertility