All Phenotypes Stn1<em1Chwh> MGI Mouse

increased incidence of tumors by chemical induction ( J:335558 )

• following tamoxifen treatment, incidence of colorectal cancer polyps induced by exposure to azoxymethane (AOM) is increased at 30 weeks post exposure

• in addition, AOM-induced tumor number, size and malignancy are increased in tamoxifen treated mice with a higher percentage of adenocarcinomas

abnormal tumor pathology ( J:335558 )

• in tamoxifen treated mice, AOM-induced tumors display increased proliferation and reduced apoptosis

abnormal cell physiology ( J:335558 )

• increased sensitivity to DNA methylating agents in tamoxifen treated MEFs

• tamoxifen treated MEFs show accumulate DNA alkylation

increased cellular sensitivity to DNA damaging agents ( J:335558 )

• in tamoxifen treated mice, AOM-induced DNA damage in the colon is increased

increased cellular sensitivity to oxidative stress ( J:335558 )

• tamoxifen treated MEFs show increased sensitivity to oxidative damage

decreased apoptosis ( J:335558 )

• in tamoxifen treated mice, AOM-induced tumors display reduced apoptosis

increased cell proliferation ( J:335558 )

• in tamoxifen treated mice, AOM-induced tumors display increased proliferation

abnormal DNA repair ( J:335558 )

• MEFs treated with tamoxifen show an increase in the percentage of tail DNA and an increase in gammaH2AX staining with or without AOM exposure

decreased DNA replication ( J:335558 )

• following tamoxifen treatment iododeoxyuridine lengths are significantly shorter regardless of AOM treatment