Phenotypes associated with this allele

• Allele Symbol: Znrf4^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:8224225
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Znrf4^em1Osb/Znrf4^em1Osb	B6;D2-Znrf4^em1Osb/Osb	MGI:8288870

Genotype
MGI:8288870

hm1

• Allelic Composition: Znrf4^em1Osb/Znrf4^em1Osb
• Genetic Background: B6;D2-Znrf4^em1Osb/Osb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:370030 )

♂N • males exhibit normal testis gross appearance, testis weight/body weight ratios, testis and epididymis histology, and normal cauda epididymal sperm motility with no major changes in sperm kinetic parameters relative to aged-matched heterozygous littermates; males sire pups with normal average litter sizes when paired with wild-type females

teratozoospermia ( J:370030 )

♂ • nearly 70% of cauda epididymal spermatozoa show morphological defects

abnormal sperm head morphology ( J:370030 )

♂ • abnormal cauda epididymal spermatozoa exhibit bent sperm heads, loss of apical hook, and irregular-shaped sperm heads

cellular

teratozoospermia ( J:370030 )

♂ • nearly 70% of cauda epididymal spermatozoa show morphological defects

abnormal sperm head morphology ( J:370030 )

♂ • abnormal cauda epididymal spermatozoa exhibit bent sperm heads, loss of apical hook, and irregular-shaped sperm heads