Phenotypes associated with this allele

• Allele Symbol: Eda^em1Ywu
• Allele Name: endonuclease-mediated mutation 1, Yiqun Wu
• Allele ID: MGI:8209579
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	\Eda^em1Ywu/\Eda^em1Ywu	C57BL/6J-Eda^em1Ywu	MGI:8209648
ot2	\Eda^em1Ywu/Y	C57BL/6J-Eda^em1Ywu	MGI:8209584

Genotype
MGI:8209648

hm1

• Allelic Composition: \Eda^em1Ywu/\Eda^em1Ywu
• Genetic Background: C57BL/6J-Eda^em1Ywu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal molar cusp morphology ( J:363034 )

♀ • mice exhibit molars with flattened, rounded cusps

endocrine/exocrine glands

abnormal eccrine sweat gland morphology ( J:363034 )

♀ • formation of sweat glands is reduced, with an intermediate level of defect compared to knock-out mice

hypohidrosis ( J:363034 )

♀ • mice show reduced sweating function, with an intermediate level of defect compared to knock-out mice

growth/size/body

abnormal molar cusp morphology ( J:363034 )

♀ • mice exhibit molars with flattened, rounded cusps

integument

integument phenotype ( J:363034 )

♀N • mice show no obvious abnormalities in abdomen hair, behind ear hair, hair around the eyes or tail hair and tips

abnormal eccrine sweat gland morphology ( J:363034 )

♀ • formation of sweat glands is reduced, with an intermediate level of defect compared to knock-out mice

hypohidrosis ( J:363034 )

♀ • mice show reduced sweating function, with an intermediate level of defect compared to knock-out mice

limbs/digits/tail

abnormal eccrine sweat gland morphology ( J:363034 )

♀ • formation of sweat glands is reduced, with an intermediate level of defect compared to knock-out mice

skeleton

abnormal molar cusp morphology ( J:363034 )

♀ • mice exhibit molars with flattened, rounded cusps

Genotype
MGI:8209584

ot2

• Allelic Composition: \Eda^em1Ywu/Y
• Genetic Background: C57BL/6J-Eda^em1Ywu

craniofacial

abnormal molar cusp morphology ( J:363034 )

♂ • molars show more flattened, rounded cusps different from the deep and defined cusps of wild-type molars

♂ • however, the number and size of mandibular molars are normal and no obvious taurodontism malformations are seen in the lower second molar

endocrine/exocrine glands

abnormal eccrine sweat gland morphology ( J:363034 )

♂ • formation of sweat glands is reduced, with an intermediate level of defect compared to knock-out mice

hypohidrosis ( J:363034 )

♂ • mice show reduced sweating function, with an intermediate level of defect compared to knock-out mice

♂ • sweating defects are more severe than those of Eda^em3Ywu/Y

growth/size/body

abnormal molar cusp morphology ( J:363034 )

♂ • molars show more flattened, rounded cusps different from the deep and defined cusps of wild-type molars

♂ • however, the number and size of mandibular molars are normal and no obvious taurodontism malformations are seen in the lower second molar

integument

integument phenotype ( J:363034 )

♂N • mice show no obvious abnormalities in abdomen hair, behind ear hair, hair around the eyes or tail hair and tips and no significant decrease in the number of hair follicles

abnormal eccrine sweat gland morphology ( J:363034 )

♂ • formation of sweat glands is reduced, with an intermediate level of defect compared to knock-out mice

hypohidrosis ( J:363034 )

♂ • mice show reduced sweating function, with an intermediate level of defect compared to knock-out mice

♂ • sweating defects are more severe than those of Eda^em3Ywu/Y

limbs/digits/tail

abnormal eccrine sweat gland morphology ( J:363034 )

♂ • formation of sweat glands is reduced, with an intermediate level of defect compared to knock-out mice

skeleton

abnormal molar cusp morphology ( J:363034 )

♂ • molars show more flattened, rounded cusps different from the deep and defined cusps of wild-type molars

♂ • however, the number and size of mandibular molars are normal and no obvious taurodontism malformations are seen in the lower second molar