Phenotypes associated with this allele

• Allele Symbol: Bcl2l13^tm2.1Otsu
• Allele Name: targeted mutation 2.1, Kinya Otsu
• Allele ID: MGI:8206330
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2l13^tm2.1Otsu/Bcl2l13^tm2.1Otsu	Not Specified	MGI:8242680

Genotype
MGI:8242680

hm1

• Allelic Composition: Bcl2l13^tm2.1Otsu/Bcl2l13^tm2.1Otsu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response of heart to induced stress ( J:360813 )

• mice subjected to pressure overload via transverse aortic constriction (TAC) exhibit left ventricular (LV) chamber dilation and cardiac dysfunction 4 weeks after surgery

• the LV weight-to-tibia length ratio is increased to a greater extent than in wild-type mice after TAC

• TAC-operated mice exhibit more severe cardiac hypertrophy and larger fibrosis fractions and cross-sectional areas of cardiomyocytes than TAC-operated wild-type mice

decreased cellular ATP level ( J:360813 )

• cytosolic ATP concentration in TAC-operated hearts is lower

abnormal mitophagy ( J:360813 )

• TAC-operated mice exhibit lower levels of mitophagy

cardiovascular system

abnormal myocardial fiber morphology ( J:360813 )

• cardiomyocyte cross-sectional area is larger in the TAC-operated mice compared to TAC-operated wild-type mice

abnormal myocardial fiber mitochondrial morphology ( J:360813 )

• the population of mitochondria with longer lengths and smaller mitochondrial areas is increased in TAC-operated hearts

cardiac fibrosis ( J:360813 )

• TAC-operated hearts exhibit larger fibrosis fractions and cross-sectional areas of cardiomyocytes than TAC-operated wild-type mice

abnormal response of heart to induced stress ( J:360813 )

• mice subjected to pressure overload via transverse aortic constriction (TAC) exhibit left ventricular (LV) chamber dilation and cardiac dysfunction 4 weeks after surgery

• the LV weight-to-tibia length ratio is increased to a greater extent than in wild-type mice after TAC

• TAC-operated mice exhibit more severe cardiac hypertrophy and larger fibrosis fractions and cross-sectional areas of cardiomyocytes than TAC-operated wild-type mice

cellular

abnormal myocardial fiber mitochondrial morphology ( J:360813 )

• the population of mitochondria with longer lengths and smaller mitochondrial areas is increased in TAC-operated hearts

decreased cellular ATP level ( J:360813 )

• cytosolic ATP concentration in TAC-operated hearts is lower

abnormal mitophagy ( J:360813 )

• TAC-operated mice exhibit lower levels of mitophagy

muscle

abnormal myocardial fiber morphology ( J:360813 )

• cardiomyocyte cross-sectional area is larger in the TAC-operated mice compared to TAC-operated wild-type mice

abnormal myocardial fiber mitochondrial morphology ( J:360813 )

• the population of mitochondria with longer lengths and smaller mitochondrial areas is increased in TAC-operated hearts