Phenotypes associated with this allele

• Allele Symbol: 1700052I22Rik^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:8204801
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	1700052I22Rik^em1Bcgen/1700052I22Rik^em1Bcgen	C57BL/6-1700052I22Rik^em1Bcgen	MGI:8204803

Genotype
MGI:8204803

hm1

• Allelic Composition: 1700052I22Rik^em1Bcgen/1700052I22Rik^em1Bcgen
• Genetic Background: C57BL/6-1700052I22Rik^em1Bcgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal seminiferous tubule morphology ( J:362994 )

♂ • seminiferous tubules exhibit multicellular structures within the central lumen and shedding of round spermatids

abnormal seminiferous tubule epithelium morphology ( J:362994 )

♂ • mice exhibit reduced diameter and thinner seminiferous epithelium

abnormal spermatogenesis ( J:362994 )

♂ • spermatid chromatin condensation is defective

oligozoospermia ( J:362994 )

♂

abnormal sperm head morphology ( J:362994 )

♂ • approximately 51.4% of mature spermatozoa from the cauda epididymis exhibit defective head morphology, with the most common abnormality being spherical heads

globozoospermia ( J:362994 )

♂ • the most common head defect is spherical heads

decreased elongated spermatid number ( J:362994 )

♂

decreased round spermatid number ( J:362994 )

♂ • decline in the number of round spermatids but not in spermatocyte count, indicating compromised round spermatid production

reduced male fertility ( J:362994 )

♂ • males exhibit lower fecundity, producing 5.5 pups versus 7.4 pups in wild-type mice, when mated with wild-type females

♂ • however, no differences in testis and epididymis sizes are seen

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:362994 )

♂ • seminiferous tubules exhibit multicellular structures within the central lumen and shedding of round spermatids

abnormal seminiferous tubule epithelium morphology ( J:362994 )

♂ • mice exhibit reduced diameter and thinner seminiferous epithelium

cellular

oligozoospermia ( J:362994 )

♂

abnormal sperm head morphology ( J:362994 )

♂ • approximately 51.4% of mature spermatozoa from the cauda epididymis exhibit defective head morphology, with the most common abnormality being spherical heads

globozoospermia ( J:362994 )

♂ • the most common head defect is spherical heads

decreased elongated spermatid number ( J:362994 )

♂

decreased round spermatid number ( J:362994 )

♂ • decline in the number of round spermatids but not in spermatocyte count, indicating compromised round spermatid production