Phenotypes associated with this allele

• Allele Symbol: Mroh2b^tm1.1Mkob
• Allele Name: targeted mutation 1.1, Moira K O'Bryan
• Allele ID: MGI:8192118
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mroh2b^tm1.1Mkob/Mroh2b^tm1.1Mkob	involves: C57BL/6 * CBA	MGI:8192140
ht2	Mroh2b^tm1.1Mkob/Mroh2b^+	involves: C57BL/6 * CBA	MGI:8192141

Genotype
MGI:8192140

hm1

• Allelic Composition: Mroh2b^tm1.1Mkob/Mroh2b^tm1.1Mkob
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage, complete penetrance ( J:236944 )

• no mice are obtained and no embryos are recovered at 10-16 dpc, indicating that embryos die before 10 dpc

Genotype
MGI:8192141

ht2

• Allelic Composition: Mroh2b^tm1.1Mkob/Mroh2b⁺
• Genetic Background: involves: C57BL/6 * CBA

reproductive system

abnormal spermatid morphology ( J:236944 )

• elevated DNA damage in testes, with DNA damage detected in spermatids

transmission ratio distortion ( J:236944 )

• ratio of heterozygote to wild-type offspring is 6:1 rather than the expected 2:1 without change in fertility, testes histomorphology, or sperm viability and motility and male and female offspring are produced at the normal ratios

cellular

abnormal spermatid morphology ( J:236944 )

• elevated DNA damage in testes, with DNA damage detected in spermatids