Phenotypes associated with this allele

• Allele Symbol: Eepd1^em2Lju
• Allele Name: endonuclease-mediated mutation 2, Junli Liu
• Allele ID: MGI:8190723
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eepd1^em2Lju/Eepd1^em2Lju	C57BL/6J-Eepd1^em2Lju	MGI:8190735

Genotype
MGI:8190735

hm1

• Allelic Composition: Eepd1^em2Lju/Eepd1^em2Lju
• Genetic Background: C57BL/6J-Eepd1^em2Lju

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body fat mass ( J:363069 )

• mice fed a high-fat diet exhibit higher total fat mass, despite similar food intake to controls

increased susceptibility to diet-induced obesity ( J:363069 )

• mice fed a high-fat diet exhibit higher body weight

adipose tissue

increased total body fat amount ( J:363069 )

• adipose depots are enlarged in high-fat diet fed mice

increased body fat mass ( J:363069 )

• mice fed a high-fat diet exhibit higher total fat mass, despite similar food intake to controls

increased fat cell size ( J:363069 )

• adipocytes in the iWAT, eWAT and BAT of high-fat diet fed mice are larger

increased brown fat cell size ( J:363069 )

• in mice fed a high-fat diet

increased white fat cell size ( J:363069 )

• in mice fed a high-fat diet

homeostasis/metabolism

impaired adaptive thermogenesis ( J:363069 )

• mice fed a high-fat diet show reduced tolerance to cold conditions and show decreased thermogenesis in adipose tissues

increased circulating glucose level ( J:363069 )

• mice fed a high-fat diet exhibit elevated blood glucose levels

increased circulating insulin level ( J:363069 )

• mice fed a high-fat diet exhibit elevated circulating insulin concentrations

decreased energy expenditure ( J:363069 )

• mice fed a high-fat diet exhibit deceased energy expenditure

increased susceptibility to diet-induced obesity ( J:363069 )

• mice fed a high-fat diet exhibit higher body weight

impaired glucose tolerance ( J:363069 )

• mice fed a high-fat diet show impaired glucose tolerance

insulin resistance ( J:363069 )

• insulin tolerance test shows an impairment in insulin sensitivity in mice fed a high-fat diet