Phenotypes associated with this allele

• Allele Symbol: Eepd1^em1Lju
• Allele Name: endonuclease-mediated mutation 1, Junli Liu
• Allele ID: MGI:8190679
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eepd1^em1Lju/Eepd1^em1Lju Tg(Adipoq-cre)1Evdr/0	involves: C57BL/6J * FVB/NJ	MGI:8190725

Genotype
MGI:8190725

cn1

• Allelic Composition: Eepd1^em1Lju/Eepd1^em1Lju; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body fat mass ( J:363069 )

• mice fed a high-fat diet exhibit an increase in fat mass

increased susceptibility to age related obesity ( J:363069 )

• mice fed a standard diet exhibit an increase in body weight during middle age

• however, mice show no alterations in food consumption

increased susceptibility to diet-induced obesity ( J:363069 )

• 6-week-old mice challenged with a high-fat diet for 3 months exhibit increased body weight despite maintaining normal food intake, indicating a greater diet-induced obesity

adipose tissue

increased white adipose tissue amount ( J:363069 )

• mice fed a high-fat diet show a greater expansion of iWAT and eWAT compared to controls

increased total body fat amount ( J:363069 )

• mice fed a standard diet show an increase in the volume of all three adipose tissue types

increased body fat mass ( J:363069 )

• mice fed a high-fat diet exhibit an increase in fat mass

abnormal brown adipose tissue morphology ( J:363069 )

• accumulation of lipids in the brown adipose tissue (BAT)

• mice fed a high-fat diet accumulate more lipids in BAT

increased white fat cell size ( J:363069 )

• adipocytes are enlarged in both the iWAT and eWAT

• mice fed a high-fat diet show a larger size of adipocytes within iWAT and eWAT

homeostasis/metabolism

impaired adaptive thermogenesis ( J:363069 )

• mice exposed to acute cold conditions exhibit a compromised ability to maintain their core body temperature under cold stress and show lower surface temperature, indicating reduced heat production

• mice fed a high-fat diet have an impaired capacity to maintain their core temperature during cold exposure and surface temperature is downregulated

increased circulating insulin level ( J:363069 )

decreased energy expenditure ( J:363069 )

• mice exhibit deceased energy expenditure; this decrease is not attributed to changes in locomotor activity

• energy expenditure is lower in mice fed a high-fat diet

• however, mice exhibit normal respiratory exchange ratio when fed either a standard diet or high-fat diet

increased susceptibility to diet-induced obesity ( J:363069 )

• 6-week-old mice challenged with a high-fat diet for 3 months exhibit increased body weight despite maintaining normal food intake, indicating a greater diet-induced obesity

impaired glucose tolerance ( J:363069 )

• glucose tolerance test shows impaired glucose tolerance in middle-aged mice

insulin resistance ( J:363069 )

• insulin tolerance test shows an impairment in insulin sensitivity in middle-aged mice

• mice fed a high-fat diet exhibit worse whole-body insulin sensitivity than high-fat fed controls