Phenotypes associated with this allele

• Allele Symbol: Zfp697^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:8187614
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	\Zfp697^em1Bcgen/\Zfp697^em1Bcgen \Tg(Myog-cre)1Eno/0	involves: C57BL/6N	MGI:8187615

Genotype
MGI:8187615

cn1

• Allelic Composition: \Zfp697^em1Bcgen/\Zfp697^em1Bcgen; \Tg(Myog-cre)1Eno/0
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:362025 )

♀N • no baseline differences in exercise performance or grip strength

decreased grip strength ( J:362025 )

♂ • fail to recover grip strength at 96 h after downhill running induced muscle damage unlike wild-type controls

♂ • however, no baseline differences in exercise performance or grip strength are seen

abnormal gait ( J:362025 )

♀ • following intramuscular cardiotoxin injection, decline in various gait parameters is more pronounced compared to wild-type controls

growth/size/body

decreased lean body mass ( J:362025 )

♀ • delay in recovery of lean mass during the reloading phase in an unloading/reloading assay

muscle

muscle phenotype ( J:362025 )

N • no baseline differences in muscle tissue mass

decreased skeletal muscle weight ( J:362025 )

♀ • upon reloading recovery of muscle mass is impaired in the gastrocnemius and tibialis anterior muscles

abnormal muscle physiology ( J:362025 )

♀ • during the unloading phase of a unloading/reloading study, muscle wasting is reduced in the tibialis anterior but not in other hindlimb muscles

♀ • however, upon reloading recovery of muscle mass is impaired in the gastrocnemius and tibialis anterior muscles

impaired skeletal muscle regeneration ( J:362025 )

• upon reloading recovery of muscle mass is impaired in the gastrocnemius and tibialis anterior muscles

• fail to activate regenerative gene program in muscle after injury