Phenotypes associated with this allele

• Allele Symbol: Or10p1^em1Wanyg
• Allele Name: endonuclease-mediated mutation 1, Yiguo Wang
• Allele ID: MGI:8187417
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Or10p1^em1Wanyg/Or10p1^em1Wanyg	involves: C57BL/6J	MGI:8187422

Genotype
MGI:8187422

hm1

• Allelic Composition: Or10p1^em1Wanyg/Or10p1^em1Wanyg
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased alertness ( J:365327 )

• fewer bouts of torpor under fasting conditions

increased locomotor activity ( J:365327 )

• under fasting conditions

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:365327 )

N • no abnormalities in body weight, food intake, water intake, fat mass, energy expenditure, RER, movement, triglyceride levels, cholesterol levels, plasma free fatty acid levels or plasma glycerol levels

abnormal homeostasis ( J:365327 )

• famsin (Gm11437) induced changes seen in wild-type controls are abolished

decreased fasting circulating glucose level ( J:365327 )

• after overnight fasting

• however, blood glucose levels are similar to controls under ad lib feeding

decreased circulating ketone body level ( J:365327 )

• decreased plasma beta-hydroxybutyrate levels aster overnight fast

abnormal body temperature homeostasis ( J:365327 )

• impaired starvation resistance as measured by body temperature dropping below 28^oC followed by a quick decrease to below the environmental temperature

impaired gluconeogenesis ( J:365327 )

• attenuated gluconeogenic capacity

increased insulin sensitivity ( J:365327 )

abnormal metabolism ( J:365327 )

• decreased expression of genes involved in metabolic adaptations to fasting

liver/biliary system

abnormal liver physiology ( J:365327 )

• decreased liver acetyl-CoA levels after overnight fasting

nervous system

abnormal nervous system physiology ( J:365327 )

• treatment with Gm11437 (famsin) fails to increase cAMP levels in the olfactory bulb unlike in wild-type controls