mortality/aging
• a reduction in the percentage of homozygotes (both males and females) is seen at P21, however normal numbers are seen at E17.5 and P7, indicating partial lethality between P7 and P21
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growth/size/body
• weight is normal at E17.5, but P7 males and females show reduced weight
• P14 males show reduced weight, while females only show a trend towards reduced weight and P21 males and females show reduced weight indicating mice from P7 to 6 months have delayed weight gain for both males and females
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behavior/neurological
• homozygotes bred beyond F6 generations exhibit hindlimb clasping; this includes 5 of 6 F8 homozygotes at 3.2 months and 19 of 20 F10 homozygotes at 2.8-3 months of age
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• seizure-like behaviors appear at 7 months of age
• seizure-like behaviors include momentary or sustained freezing, whisker twitching and head bobbing and wild jumping
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nervous system
• seizure-like behaviors appear at 7 months of age
• seizure-like behaviors include momentary or sustained freezing, whisker twitching and head bobbing and wild jumping
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vision/eye
N |
• no cataracts are seen in 1.5-5-month-old mice
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