All Phenotypes D1Pas1<em1Dean> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

D1Pas1^em1Dean
endonuclease-mediated mutation 1, Jurrien Dean
MGI:8169118

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	D1Pas1^em1Dean/D1Pas1^em1Dean	involves: C57BL/6 * DBA/2	MGI:8169143
cx2	D1Pas1^em1Dean/D1Pas1^em1Dean Tg(Btbd18/mCherry)#Dean/0	involves: C57BL/6 * DBA/2	MGI:8169146

Allelic Composition	D1Pas1^em1Dean/D1Pas1^em1Dean
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
D1Pas1^em1Dean mutation (0 available); any D1Pas1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

small testis ( J:360837 )

• reduction in testes size in adults which is attributed to missing cell populations beyond the late pachytene spermatocyte stage

arrest of spermatogenesis ( J:360837 )

• spermatogenic arrest in late pachytene spermatocytes

• a higher amount of R-loop structures are detected in the testis, especially in the pachytene spermatocyte nucleoplasm

male infertility ( J:360837 )

endocrine/exocrine glands