Phenotypes associated with this allele

• Allele Symbol: Sf3b2^em1Sqiu
• Allele Name: endonuclease-mediated mutation 1, Shenfeng Qiu
• Allele ID: MGI:8166512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sf3b2^em1Sqiu/Sf3b2^em1Sqiu	C57BL/6-Sf3b2^em1Sqiu	MGI:8166767

Genotype
MGI:8166767

hm1

• Allelic Composition: Sf3b2^em1Sqiu/Sf3b2^em1Sqiu
• Genetic Background: C57BL/6-Sf3b2^em1Sqiu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:360860 )

behavior/neurological

impaired spatial learning ( J:360860 )

• mice show slower learning during the acquisition period of the Morris water maze training phase at approximately 2 months of age

abnormal long-term spatial reference memory ( J:360860 )

• mice spend less time in the target quadrant during the Morris water maze probe trial at approximately 2 months of age

impaired spatial memory extinction ( J:360860 )

• mice sow slower learning of the new platform location during the reverse learning period at approximately 2 months of age

nervous system

abnormal excitatory postsynaptic potential ( J:360860 )

• hippocampal slices exhibit reduced levels of tetanus-induced potentiation of fEPSP slopes

reduced long-term potentiation ( J:360860 )

• field potential recordings show impaired long-term potentiation (LTP) at the CA3>CA1 synapse