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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tent5bem1Adki
endonuclease-mediated mutation 1, Andrzej Dziembowski
MGI:8164230
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		\Tent5bem1Adki/\Tent5bem1Adki involves: C57BL/6JTar * CBA/WTar MGI:8164370
cx2
 		\Tent5bem1Adki/\Tent5bem1Adki
\Tent5cem1Adki/\Tent5cem1Adki 		involves: C57BL/6JTar * CBA/WTar MGI:8164375


Genotype
MGI:8164370
hm1
Allelic
Composition		 \Tent5bem1Adki/\Tent5bem1Adki
Genetic
Background		 involves: C57BL/6JTar * CBA/WTar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tent5bem1Adki mutation (0 available); any Tent5b mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:360869 )
N
• mice exhibit normal fertility




Genotype
MGI:8164375
cx2
Allelic
Composition		 \Tent5bem1Adki/\Tent5bem1Adki
\Tent5cem1Adki/\Tent5cem1Adki
Genetic
Background		 involves: C57BL/6JTar * CBA/WTar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tent5bem1Adki mutation (0 available); any Tent5b mutation (17 available)
Tent5cem1Adki mutation (0 available); any Tent5c mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oocyte degeneration ( J:360869 )
• degeneration of preovulatory prophase I oocytes
increased ovary apoptosis ( J:360869 )
• ovaries show high levels of apoptosis, not only within oocytes but also in surrounding granulosa cells
abnormal oogenesis ( J:360869 )
• early oogenesis arrest, with degeneration of preovulatory prophase I oocytes
• 8-week-old ovaries show oocytes in various stages of degeneration and cell death
• 5-week-old ovaries have oocytes that show initial signs of degeneration, with 35% of oocytes remaining in the living state and the remainder showing various abnormalities

endocrine/exocrine glands
increased ovary apoptosis ( J:360869 )
• ovaries show high levels of apoptosis, not only within oocytes but also in surrounding granulosa cells
absent corpus luteum ( J:360869 )
• the presence of corpora lutea (indicating previous ovulation) are not seen
absent tertiary ovarian follicles ( J:360869 )
• mature antral follicles ready for ovulation are not seen
impaired ovarian folliculogenesis ( J:360869 )
• smaller ovaries with arrest of follicular growth at the early antral stage and no sighs of significant follicular growth
• ovarian follicle growth cannot be restored by hormonal stimulation with pregnant mates serum gonadotropin (PMSG) or human chorionic gonadotropin (hCG)
small ovary ( J:360869 )
• smaller ovaries with no sighs of significant follicular growth or earlier ovulation

reproductive system
oocyte degeneration ( J:360869 )
• degeneration of preovulatory prophase I oocytes
increased ovary apoptosis ( J:360869 )
• ovaries show high levels of apoptosis, not only within oocytes but also in surrounding granulosa cells
abnormal oogenesis ( J:360869 )
• early oogenesis arrest, with degeneration of preovulatory prophase I oocytes
• 8-week-old ovaries show oocytes in various stages of degeneration and cell death
• 5-week-old ovaries have oocytes that show initial signs of degeneration, with 35% of oocytes remaining in the living state and the remainder showing various abnormalities
absent corpus luteum ( J:360869 )
• the presence of corpora lutea (indicating previous ovulation) are not seen
absent tertiary ovarian follicles ( J:360869 )
• mature antral follicles ready for ovulation are not seen
impaired ovarian folliculogenesis ( J:360869 )
• smaller ovaries with arrest of follicular growth at the early antral stage and no sighs of significant follicular growth
• ovarian follicle growth cannot be restored by hormonal stimulation with pregnant mates serum gonadotropin (PMSG) or human chorionic gonadotropin (hCG)
small ovary ( J:360869 )
• smaller ovaries with no sighs of significant follicular growth or earlier ovulation
anovulation ( J:360869 )
• no ovulation
• ovulation cannot be restored by hormonal stimulation with pregnant mates serum gonadotropin (PMSG) or human chorionic gonadotropin (hCG)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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