Phenotypes associated with this allele

• Allele Symbol: Slc22a7^em1Araka
• Allele Name: endonuclease-mediated mutation 1, Hiroshi Arakawa
• Allele ID: MGI:8161223
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc22a7^em1Araka/Slc22a7^em1Araka	involves: C57BL/6J	MGI:8164025

Genotype
MGI:8164025

hm1

• Allelic Composition: Slc22a7^em1Araka/Slc22a7^em1Araka
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal xenobiotic metabolism ( J:350422 )

• primary cultured hepatocytes from 8-week-old male mice show a ~51.9% reduction in glucuronidation efficiency for bumetanide (a known substrate of SLC22A7), as calculated by dividing the production of bumetanide beta-glucuronide by accumulation of bumetanide into hepatocytes

• however, cellular uptake of bumetanide into hepatocytes and the glucuronidation activity directly assessed in hepatic microsomes are not affected