Phenotypes associated with this allele

• Allele Symbol: Dclk3^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:8158768
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dclk3^tm1.1Geno/Dclk3^tm1.1Geno	involves: C57BL/6N	MGI:8159458
cn2	Dclk3^tm1.1Geno/Dclk3^tm1.1Geno Rgs9^tm1.1(cre)Yql/Rgs9^+	Not Specified	MGI:8159456

Genotype
MGI:8159458

cn1

• Allelic Composition: Dclk3^tm1.1Geno/Dclk3^tm1.1Geno
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:361634 )

N • mice injected with an adenovirus expressing cre recombinase in the striatum show no differences on the rotarod at 8 months of age

abnormal long-term spatial reference memory ( J:361634 )

• mice injected with an adenovirus expressing cre recombinase in the hippocampus at 4 months of age show spatial memory deficits in the Morris water maze two months later, showing equal exploration of all quadrants of the swimming pool

Genotype
MGI:8159456

cn2

• Allelic Composition: Dclk3^tm1.1Geno/Dclk3^tm1.1Geno; Rgs9^{tm1.1(cre)Yql}/Rgs9⁺
• Genetic Background: Not Specified

normal phenotype

no abnormal phenotype detected ( J:361634 )

• mice grow normally, show no obvious morphological abnormalities, show no major behavioral deficits (in spontaneous locomotor activity, rotarod test, anxiety tests), and no major anomalies in the striatum or in levels of metabolites in the striatum