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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Map4em1Coop
endonuclease-mediated mutation 1, Thomas A Cooper
MGI:7865835
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Map4em1Coop/Map4em1Coop FVB/NJ-Map4em1Coop MGI:7865850


Genotype
MGI:7865850
hm1
Allelic
Composition
Map4em1Coop/Map4em1Coop
Genetic
Background
FVB/NJ-Map4em1Coop
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map4em1Coop mutation (0 available); any Map4 mutation (230 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• significantly decreased in males and females at 10 weeks of age

growth/size/body
• decreased body weight but no significant difference in isolated muscle weights

muscle
N
• no signs of muscle cell loss or atrophy in the gastrocnemius muscles
• increase in the ratio of longitudinal to transverse of the core myofiber microtubules in the flexor digitorum brevis
• however, organization of surface microtubules and levels of tubulin are similar to wild-type
• lower force generation that worsens as contraction frequency increased in isolated extensor digitorum longus and soleus muscles stimulated at different frequencies





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory