behavior/neurological
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• significantly decreased in males and females at 10 weeks of age
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growth/size/body
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• decreased body weight but no significant difference in isolated muscle weights
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muscle
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• no signs of muscle cell loss or atrophy in the gastrocnemius muscles
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• increase in the ratio of longitudinal to transverse of the core myofiber microtubules in the flexor digitorum brevis
• however, organization of surface microtubules and levels of tubulin are similar to wild-type
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• lower force generation that worsens as contraction frequency increased in isolated extensor digitorum longus and soleus muscles stimulated at different frequencies
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