Phenotypes associated with this allele

• Allele Symbol: Map4^em1Coop
• Allele Name: endonuclease-mediated mutation 1, Thomas A Cooper
• Allele ID: MGI:7865835
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map4^em1Coop/Map4^em1Coop	FVB/NJ-Map4^em1Coop	MGI:7865850

Genotype
MGI:7865850

hm1

• Allelic Composition: Map4^em1Coop/Map4^em1Coop
• Genetic Background: FVB/NJ-Map4^em1Coop

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:358165 )

♂ • significantly decreased in males and females at 10 weeks of age

growth/size/body

decreased body weight ( J:358165 )

♂ • decreased body weight but no significant difference in isolated muscle weights

muscle

muscle phenotype ( J:358165 )

♂N • no signs of muscle cell loss or atrophy in the gastrocnemius muscles

abnormal skeletal muscle fiber morphology ( J:358165 )

♂ • increase in the ratio of longitudinal to transverse of the core myofiber microtubules in the flexor digitorum brevis

♂ • however, organization of surface microtubules and levels of tubulin are similar to wild-type

impaired skeletal muscle contractility ( J:358165 )

♂ • lower force generation that worsens as contraction frequency increased in isolated extensor digitorum longus and soleus muscles stimulated at different frequencies