Analysis Tools
mortality/aging
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• fewer than the expected number of homozygotes are seen at P21 from heterozygous intercrosses
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homeostasis/metabolism
 |
• intraperitoneal glucose tolerance remains normal at 8 weeks of age but males at 20 weeks of age show a moderate glucose intolerance on chow diet while females remain glucose tolerant regardless of diet or age
• however, both males and females at 12 and 22 weeks of age remain insulin sensitive in the intraperitoneal insulin tolerance test and fasted insulin levels are normal at 14 and 24 weeks of age, and no change in fasted blood glucose levels are seen independent of diet and age indicating an absence of diabetic phenotype
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endocrine/exocrine glands
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• males on a chow diet have larger islets than controls
• however, under high-fat diet conditions, males fail to increase islet size and islet number in response to the metabolic challenge to the same extent as seen in wild-type mice
• no changes are seen in pancreas weight or islet architecture with no shift in relative prevalence in beta- and alpha-cells
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growth/size/body
| N |
• no change in body weight is seen independent of diet and age
• mice on chow and high-fat diet show no differences in fat and lean mass compared to wild-type mice on the same diet
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | maturity-onset diabetes of the young type 4 | DOID:0111103 |
OMIM:606392 |
J:391114 |
