Phenotypes associated with this allele

• Allele Symbol: Kank1^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7860796
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kank1^em1Cya/Kank1^em1Cya Tg(NPHS2-cre)295Lbh/0	involves: C57BL/6 * C57BL/6J * SJL/J	MGI:7860799

Genotype
MGI:7860799

cn1

• Allelic Composition: Kank1^em1Cya/Kank1^em1Cya; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

granular kidney ( J:354142 )

• sclerotic index is significantly increased at 2 and 6 months of age but not at 1 year of age

• however, urinary albumin-creatinine ratio, blood urea nitrogen, and serum creatinine levels are similar to controls at 2, 6, and 12 months of age

renal fibrosis ( J:354142 )

• increased fibrotic index at 6 months of age, but not at 2 months or 1 year of age

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:354142 )

• elevated increase in the urinary albumin-creatinine ratio following adriamycin-induced kidney injury

• however, blood urea nitrogen and serum creatinine levels in adriamycin-treated mutant mice are similar to treatment-matched controls

• after adriamycin-induced kidney injury the sclerotic index is significantly increased compared to treatment-matched controls

• marked decrease in density of foot processes in the glomerular basement membrane compared to controls