Phenotypes associated with this allele

• Allele Symbol: 2310061I04Rik^m1Ifd
• Allele Name: mutation 1, Ian Dunn
• Allele ID: MGI:7855590
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	2310061I04Rik^m1Ifd/2310061I04Rik^m1Ifd	involves: C57BL/6N	MGI:7855598
cx2	2310061I04Rik^m1Ifd/2310061I04Rik^m1Ifd Traf7^tm1.1Ifd/Traf7^tm1.1Ifd	involves: C57BL/6N	MGI:7855596
cx3	2310061I04Rik^m1Ifd/2310061I04Rik^m1Ifd Traf7^tm1.2Ifd/Traf7^tm1.2Ifd	involves: C57BL/6N	MGI:7855597

Genotype
MGI:7855598

hm1

• Allelic Composition: 2310061I04Rik^m1Ifd/2310061I04Rik^m1Ifd
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:360757 )

• die around P24

nervous system

abnormal astrocyte morphology ( J:360757 )

• ramification of fine processes looks disorganized

abnormal oligodendrocyte morphology ( J:360757 )

• cytoplasm appears smaller and contains less Nissl substance

decreased brain size ( J:360757 )

abnormal anterior commissure morphology ( J:360757 )

• dramatic decrease in myelination in the anterior commissure

• numerous vacuoles of varying sizes are present

dysmyelination ( J:360757 )

• staining indicates a decrease in total myelination

• decrease in staining intensity is seen in cross-sectioned axons but not longitudinal axon fibers in the anteroventral nuclei

• dramatic decrease in myelination in the anterior commissure

growth/size/body

postnatal growth retardation ( J:360757 )

• start to lose weight after P12

behavior/neurological

ataxia ( J:360757 )

• develop pronounced ataxia

cellular

abnormal astrocyte morphology ( J:360757 )

• ramification of fine processes looks disorganized

abnormal oligodendrocyte morphology ( J:360757 )

• cytoplasm appears smaller and contains less Nissl substance

Genotype
MGI:7855596

cx2

• Allelic Composition: 2310061I04Rik^m1Ifd/2310061I04Rik^m1Ifd; Traf7^tm1.1Ifd/Traf7^tm1.1Ifd
• Genetic Background: involves: C57BL/6N

mortality/aging

premature death ( J:360757 )

• need to be euthanized shortly after P30

growth/size/body

postnatal growth retardation ( J:360757 )

• stop gaining weight after P12

nervous system

seizures ( J:360757 )

• display seizure like behavior

behavior/neurological

ataxia ( J:360757 )

• develop pronounced ataxia

seizures ( J:360757 )

• display seizure like behavior

Genotype
MGI:7855597

cx3

• Allelic Composition: 2310061I04Rik^m1Ifd/2310061I04Rik^m1Ifd; Traf7^tm1.2Ifd/Traf7^tm1.2Ifd
• Genetic Background: involves: C57BL/6N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:360757 )

• die around E10