Phenotypes associated with this allele

• Allele Symbol: Fdx1^tm1Xch
• Allele Name: targeted mutation 1, Xinbin Chen
• Allele ID: MGI:7855429
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fdx1^tm1Xch/Fdx1^tm1Xch	involves: C57BL/6	MGI:7861672
ht2	Fdx1^tm1Xch/Fdx1^+	involves: C57BL/6	MGI:7861675

Genotype
MGI:7861672

hm1

• Allelic Composition: Fdx1^tm1Xch/Fdx1^tm1Xch
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:345826 )

• embryos die between E10.5 and E13.5

growth/size/body

decreased embryo size ( J:345826 )

embryo

abnormal embryo morphology ( J:345826 )

• embryos are abnormal

decreased embryo size ( J:345826 )

Genotype
MGI:7861675

ht2

• Allelic Composition: Fdx1^tm1Xch/Fdx1⁺
• Genetic Background: involves: C57BL/6

mortality/aging

premature death ( J:345826 )

• median lifespan of 73 weeks is shorter than in wild-type mice (117 weeks)

liver/biliary system

hepatic steatosis ( J:345826 )

• mice are highly prone to liver steatosis/steatohepatitis

cellular

abnormal cell morphology ( J:345826 )

• mouse embryo fibroblasts (MEFs) exhibit increased Nile red staining in the cytoplasm suggesting accumulation of lipid droplets

neoplasm

increased adenocarcinoma incidence ( J:345826 )

• while mice are not prone to spontaneous tumors, they exhibit a higher incidence of adenocarcinomas than wild-type mice

increased sarcoma incidence ( J:345826 )

• while mice are not prone to spontaneous tumors, they exhibit a higher incidence of sarcomas than wild-type mice