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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ppip5k2em2Yul
endonuclease-mediated mutation 2, Yutao Liu
MGI:7840357
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ppip5k2em2Yul/Ppip5k2em2Yul C57BL/6J-Ppip5k2em2Yul MGI:7840363
ht2
Ppip5k2em2Yul/Ppip5k2+ C57BL/6J-Ppip5k2em2Yul MGI:7840364


Genotype
MGI:7840363
hm1
Allelic
Composition
Ppip5k2em2Yul/Ppip5k2em2Yul
Genetic
Background
C57BL/6J-Ppip5k2em2Yul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppip5k2em2Yul mutation (0 available); any Ppip5k2 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• about 64% of corneas exhibit pathological phenotypes at 3 months of age
• 25% of eyes have some corneal abnormalities such as bullous keratinopathy/ stromal edema/ stromal scarring, deep corneal neovascularization, and opacity
• 21% of eyes have some corneal abnormalities in the form of epithelial thickening, possible damage of keratinocytes, and/or stromal changes
• some eyes have deep corneal neovascularization
• decrease in central corneal thickness, however no difference is seen in central corneal thickness between 3 and 6 months per eye
• some eyes exhibit stromal edema and/or stromal changes
• in some eyes
• some eyes exhibit stromal scarring

cardiovascular system
• some eyes have deep corneal neovascularization




Genotype
MGI:7840364
ht2
Allelic
Composition
Ppip5k2em2Yul/Ppip5k2+
Genetic
Background
C57BL/6J-Ppip5k2em2Yul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppip5k2em2Yul mutation (0 available); any Ppip5k2 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• some eyes have deep corneal neovascularization

vision/eye
• about 76% of corneas exhibit pathological phenotypes at 3 months of age
• 63% of corneas exhibit pathological phenotypes at 6 months of age
• 14% of eyes have some corneal abnormalities such as bullous keratinopathy/ stromal edema/ stromal scarring, deep corneal neovascularization, and opacity
• 15% of eyes have some corneal abnormalities in the form of epithelial thickening, possible damage of keratinocytes, and/or stromal changes
• some eyes have deep corneal neovascularization
• some eyes exhibit stromal edema and/or stromal changes
• in some eyes
• some eyes exhibit stromal scarring





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory