Phenotypes associated with this allele

• Allele Symbol: Ube2j2^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7796935
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube2j2^em1Cya/Ube2j2^em1Cya	involves: C57BL/6N * CD-1	MGI:8240150

Genotype
MGI:8240150

hm1

• Allelic Composition: Ube2j2^em1Cya/Ube2j2^em1Cya
• Genetic Background: involves: C57BL/6N * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:370390 )

♂ • sperm are completely absent in the epididymis at P60 and no spermatids are present in the seminiferous tubules

♂ • spermatocytes are absent in the lumen of some seminiferous tubules at P14 and in mature males, but not at P13

abnormal male meiosis ( J:370390 )

♂ • spermatocytes exhibit impaired homologous recombination and have unstable recombination intermediates and fail to form crossovers

♂ • number of PLK1 foci on synaptonemal complex is increased in spermatocytes and the number of CDK1 foci is decreased, suggesting that synaptonemal complex disassembly is possibly defective in spermatocytes

small testis ( J:370390 )

♂ • smaller testes in 2-month-old mice

♂ • both testis weights and testis weight/body weight ratio are reduced in P14 mice but not at P12 or P14

arrest of spermatogenesis ( J:370390 )

♂ • spermatogenesis is arrested at the pachytene stage in mature males and apoptotic cells are seen

♂ • spermatocytes are absent in the lumen of some seminiferous tubules at P14 and in mature males, but not at P13

arrest of male meiosis ( J:370390 )

♂ • spermatocytes undergo meiotic arrest at the mid-pachytene stage but exhibit normal double-strand break formation

male infertility ( J:370390 )

♂

endocrine/exocrine glands

small testis ( J:370390 )

♂ • smaller testes in 2-month-old mice

♂ • both testis weights and testis weight/body weight ratio are reduced in P14 mice but not at P12 or P14

cellular

azoospermia ( J:370390 )

♂ • sperm are completely absent in the epididymis at P60 and no spermatids are present in the seminiferous tubules

♂ • spermatocytes are absent in the lumen of some seminiferous tubules at P14 and in mature males, but not at P13

abnormal male meiosis ( J:370390 )

♂ • spermatocytes exhibit impaired homologous recombination and have unstable recombination intermediates and fail to form crossovers

♂ • number of PLK1 foci on synaptonemal complex is increased in spermatocytes and the number of CDK1 foci is decreased, suggesting that synaptonemal complex disassembly is possibly defective in spermatocytes

arrest of male meiosis ( J:370390 )

♂ • spermatocytes undergo meiotic arrest at the mid-pachytene stage but exhibit normal double-strand break formation