All Phenotypes Mfsd6l<em1Fzh> MGI Mouse

oligozoospermia ( J:359004 )

• reduced sperm concentration in the epididymides

teratozoospermia ( J:359004 )

• oligoasthenoteratozoospermia

abnormal sperm head morphology ( J:359004 )

• mice exhibit deformed sperm heads

• however, sperm flagella are normal

abnormal acrosome morphology ( J:359004 )

• the typical sickle shape of acrosome is absent

• sperm acrosomal ultrastructural defects, showing as a loose acrosomal attachment and abnormal nuclear shape

• while, spermatids show normal fusion of Golgi-derived vesicle during the Golgi phase, during the cap/acrosome phase, a wider distance is seen between the acrosome and nucleus in spermatids suggesting a failed anchor of the acrosome to the nucleus and during the maturation phase, the acrosome eventually detaches from the nuclear envelope

• irregularly shaped acrosomal matrix

detached acrosome ( J:359004 )

• detached acrosomes are frequently seen in spermatozoa

decreased sperm progressive motility ( J:359004 )

asthenozoospermia ( J:359004 )

• movement of spermatozoa is slow and moving track is abnormal

• sperm motility is reduced with reduced curvilinear velocity, straight-line velocity and average-path velocity

abnormal spermiogenesis ( J:359004 )

• defective development of the acrosome

• fewer elongating spermatids are seen

reduced male fertility ( J:359004 )

• fertility of males is severely reduced