Phenotypes associated with this allele

• Allele Symbol: Gm12610^em1Rwan
• Allele Name: endonuclease-mediated mutation 1, Rong Wang
• Allele ID: MGI:7785517
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gm12610^em1Rwan/Gm12610^em1Rwan	C57BL/6-Gm12610^em1Rwan	MGI:7785519

Genotype
MGI:7785519

hm1

• Allelic Composition: Gm12610^em1Rwan/Gm12610^em1Rwan
• Genetic Background: C57BL/6-Gm12610^em1Rwan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating creatinine level ( J:359024 )

• mice show decreased levels of serum creatinine following 5/6 nephrectomy to induce kidney injury/chronic kidney disease

decreased susceptibility to injury ( J:359024 )

• however, mice have no defects in renal morphology or function under basal conditions

• mice that undergo 5/6 nephrectomy in a 2-step surgical procedure to induce chronic kidney disease show alleviation of renal injury, with reduced serum creatinine levels and decreased systolic blood pressure, increased expression of eNOS and BDNF and decreased expression of VCAM-1 and wWF, and reduced mitochondrial fission through recovered Drp1 and Mfn2 levels, indicating alleviation of vascular endothelial cell injury

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:359024 )

• mice show decreased systolic blood pressure following 5/6 nephrectomy to induce kidney injury/chronic kidney disease