Phenotypes associated with this allele

• Allele Symbol: Mir126a^tm2.1Smoc
• Allele Name: targeted mutation 2.1. Shanghai Model Organisms Center
• Allele ID: MGI:7764896
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mir126a^tm2.1Smoc/Mir126a^tm2.1Smoc Tg(Cd4-cre)1Cwi/0	involves: C57BL/6J * C57BL/6N * DBA/2	MGI:7783544

Genotype
MGI:7783544

cn1

• Allelic Composition: Mir126a^tm2.1Smoc/Mir126a^tm2.1Smoc; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

acanthosis ( J:355195 )

• mice administered imiquimod (IMQ) to induce psoriasis show more severe acanthosis and dermal infiltrating cells than wild-type IMQ-administered mice

psoriasis ( J:355195 )

• mice administered IMQ exhibit more aggravated psoriasis compared to controls

abnormal skin physiology ( J:355195 )

• mice administered imiquimod (IMQ) to induce psoriasis show aggravation of psoriasis-like dermatitis compared to controls

dermatitis ( J:355195 )

• mice administered imiquimod (IMQ) to induce psoriasis show aggravation of psoriasis-like dermatitis compared to controls

immune system

enlarged spleen ( J:355195 )

• IMQ-administered mice show more evident splenomegaly than in IMQ-treated controls

increased T-helper 1 cell number ( J:355195 )

• the proportion of Th1 cells are increased in splenic CD4+ T cells in IMQ-administered mice compared to controls

increased T-helper 17 cell number ( J:355195 )

• the proportion of Th17 cells are increased in splenic CD4+ T cells in IMQ-administered mice compared to controls

• activated splenic naive CD4+ T cells show elevated Il17a and Il17f mRNA levels and naive CD4+ T cells cultured under Th17-polarizing conditions exhibit an increase in CD4+ IL-17A+ cells indicating promotion of Th17 cell differentiation

decreased T-helper 2 cell number ( J:355195 )

• the proportion of Th2 cells is decreased in splenic CD4+ T cells in IMQ-administered mice compared to controls

dermatitis ( J:355195 )

• mice administered imiquimod (IMQ) to induce psoriasis show aggravation of psoriasis-like dermatitis compared to controls

hematopoietic system

enlarged spleen ( J:355195 )

• IMQ-administered mice show more evident splenomegaly than in IMQ-treated controls

increased T-helper 1 cell number ( J:355195 )

• the proportion of Th1 cells are increased in splenic CD4+ T cells in IMQ-administered mice compared to controls

increased T-helper 17 cell number ( J:355195 )

• the proportion of Th17 cells are increased in splenic CD4+ T cells in IMQ-administered mice compared to controls

• activated splenic naive CD4+ T cells show elevated Il17a and Il17f mRNA levels and naive CD4+ T cells cultured under Th17-polarizing conditions exhibit an increase in CD4+ IL-17A+ cells indicating promotion of Th17 cell differentiation

decreased T-helper 2 cell number ( J:355195 )

• the proportion of Th2 cells is decreased in splenic CD4+ T cells in IMQ-administered mice compared to controls

growth/size/body

enlarged spleen ( J:355195 )

• IMQ-administered mice show more evident splenomegaly than in IMQ-treated controls