Phenotypes associated with this allele

• Allele Symbol: Slc35c2^tm1.1Pst
• Allele Name: targeted mutation 1.1, Pamela Stanley
• Allele ID: MGI:7720232
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc35c2^tm1.1Pst/Slc35c2^tm1.1Pst	B6.Cg-Slc35c2^tm1.1Pst	MGI:7720243
cx2	Slc35c1^tm1Cknr/Slc35c1^tm1Cknr Slc35c2^tm1.1Pst/Slc35c2^tm1.1Pst	129X1.Cg-Slc35c1^tm1Cknr Slc35c2^tm1.1Pst	MGI:7720262
cx3	Slc35c1^tm1Cknr/Slc35c1^tm1Cknr Slc35c2^tm1.1Pst/Slc35c2^tm1.1Pst	B6.Cg-Slc35c1^tm1Cknr Slc35c2^tm1.1Pst	MGI:7720260

Genotype
MGI:7720243

hm1

• Allelic Composition: Slc35c2^tm1.1Pst/Slc35c2^tm1.1Pst
• Genetic Background: B6.Cg-Slc35c2^tm1.1Pst

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:354047 )

• viable and fertile with no obvious defects in the skeleton, T cell or B cell development

Genotype
MGI:7720262

cx2

• Allelic Composition: Slc35c1^tm1Cknr/Slc35c1^tm1Cknr; Slc35c2^tm1.1Pst/Slc35c2^tm1.1Pst
• Genetic Background: 129X1.Cg-Slc35c1^tm1Cknr Slc35c2^tm1.1Pst

mortality/aging

preweaning lethality, complete penetrance ( J:354047 )

• early death

embryo

embryonic growth retardation ( J:354047 )

• severe

skeleton

abnormal skeleton morphology ( J:354047 )

• Background Sensitivity: skeletal phenotype in lumbar vertebrae and ribs are less severe than in double mutants on a C57BL/6J background

growth/size/body

embryonic growth retardation ( J:354047 )

• severe

Genotype
MGI:7720260

cx3

• Allelic Composition: Slc35c1^tm1Cknr/Slc35c1^tm1Cknr; Slc35c2^tm1.1Pst/Slc35c2^tm1.1Pst
• Genetic Background: B6.Cg-Slc35c1^tm1Cknr Slc35c2^tm1.1Pst

mortality/aging

preweaning lethality, complete penetrance ( J:354047 )

• early death

embryo

embryonic growth retardation ( J:354047 )

• severe

skeleton

abnormal skeleton morphology ( J:354047 )

• skeletal defect are not more severe than in mutant mice wild-type for Slc35c2

• Background Sensitivity: skeletal phenotype in lumbar vertebrae and ribs are more severe than in double mutants on a 129X1/SvJ background

abnormal sternum morphology ( J:354047 )

• deformed at E18.5

decreased rib number ( J:354047 )

• deformed or missing ribs at E18.5

decreased thoracic vertebrae number ( J:354047 )

• deformed or missing thoracic vertebrae at E18.5

decreased lumbar vertebrae number ( J:354047 )

• deformed or missing lumbar vertebrae at E18.5

growth/size/body

embryonic growth retardation ( J:354047 )

• severe