About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cep135em1Mama
endonuclease-mediated mutation 1, Marcos Malumbres
MGI:7661140
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cep135em1Mama/Cep135em1Mama involves: C57BL/6 * C57BL/6J * CBA MGI:7662411
ht2
 		Cep135em1Mama/Cep135em2Mama involves: C57BL/6 * C57BL/6J * CBA MGI:7662413


Genotype
MGI:7662411
hm1
Allelic
Composition		 Cep135em1Mama/Cep135em1Mama
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep135em1Mama mutation (0 available); any Cep135 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
microcephaly ( J:310617 )
• newborns exhibit mild primary microcephaly with an approximate 24.5% reduction in cortical area

nervous system
decreased neocortex size ( J:310617 )
• approximate 24.5% reduction in cortical area in newborns

cellular
cellular phenotype ( J:310617 )
N
• mouse embryonic fibroblasts (MEFs) do not present significant centrosome duplication defects




Genotype
MGI:7662413
ht2
Allelic
Composition		 Cep135em1Mama/Cep135em2Mama
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep135em1Mama mutation (0 available); any Cep135 mutation (69 available)
Cep135em2Mama mutation (0 available); any Cep135 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
microcephaly ( J:310617 )
• newborns exhibit mild primary microcephaly with an approximate 24.7% reduction in cortical area

nervous system
decreased neocortex size ( J:310617 )
• approximate 24.7% reduction in cortical area




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory