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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phox2bem3(cre)Heno
endonuclease-mediated mutation 3, Hideki Enomoto
MGI:7657398
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Phox2bem3(cre)Heno/Phox2b+ involves: 129 * C57BL/6 * C57BL/6N * DBA MGI:7736348
cn2
 		Pcgf1tm1.1Hko/Pcgf1tm1.1Hko
Phox2bem3(cre)Heno/Phox2b+ 		involves: 129 * C57BL/6 * C57BL/6N * DBA MGI:7736341


Genotype
MGI:7736348
ht1
Allelic
Composition		 Phox2bem3(cre)Heno/Phox2b+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2bem3(cre)Heno mutation (0 available); any Phox2b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:344865 )
• slight growth retardation at 3 and 8 weeks of age




Genotype
MGI:7736341
cn2
Allelic
Composition		 Pcgf1tm1.1Hko/Pcgf1tm1.1Hko
Phox2bem3(cre)Heno/Phox2b+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcgf1tm1.1Hko mutation (1 available); any Pcgf1 mutation (20 available)
Phox2bem3(cre)Heno mutation (0 available); any Phox2b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:344865 )
• only half of mutants survive to adulthood

growth/size/body
decreased body size ( J:344865 )
• at 3 weeks of age
postnatal growth retardation ( J:344865 )
• at 3 weeks of age but catch up to controls (mice carrying just the recombinase allele) by 8 weeks of age

digestive/alimentary system
abnormal feces composition ( J:344865 )
• lighter and drier feces
abnormal colon morphology ( J:344865 )
• decrease in the number of the somatostatin-expressing neurons in the proximal colon
• increase in the number of calbindin-expressing neurons in the proximal colon
abnormal ileum morphology ( J:344865 )
• decrease in the number of the somatostatin-expressing neurons in the ileum
abnormal jejunum morphology ( J:344865 )
• decrease in the number of the somatostatin-expressing neurons in the jejunum
abnormal intestinal transit time ( J:344865 )
• increased total gastrointestinal transit time

nervous system
decreased neuron number ( J:344865 )
• decrease in the number of the somatostatin-expressing neurons in the ileum, jejunum, and proximal colon
increased neuron number ( J:344865 )
• increase in the number of calbindin-expressing neurons in the proximal colon




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory