Phenotypes associated with this allele

• Allele Symbol: Tmem241^em1Blsg
• Allele Name: endonuclease-mediated mutation 1, Bao-Liang Song
• Allele ID: MGI:7645535
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem241^em1Blsg/Tmem241^em1Blsg	involves: C57BL/6J	MGI:7645537

Genotype
MGI:7645537

hm1

• Allelic Composition: Tmem241^em1Blsg/Tmem241^em1Blsg
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

increased lung cholesterol level ( J:344360 )

• increased intracellular cholesterol levels in the lung in minor cells

• intracellular cholesterol accumulation is not seen in the heart, liver, spleen, kidney or brain

• total serum cholesterol is similar to controls

lung inflammation ( J:344360 )

• inflammatory cell infiltration

increased pulmonary alveolus wall thickness ( J:344360 )

• thickened pulmonary alveolus wall

homeostasis/metabolism

decreased aerobic running capacity ( J:344360 )

• decreased fatigue distance on a treadmill compared to controls

increased lung cholesterol level ( J:344360 )

• increased intracellular cholesterol levels in the lung in minor cells

• intracellular cholesterol accumulation is not seen in the heart, liver, spleen, kidney or brain

• total serum cholesterol is similar to controls

behavior/neurological

decreased aerobic running capacity ( J:344360 )

• decreased fatigue distance on a treadmill compared to controls

immune system

lung inflammation ( J:344360 )

• inflammatory cell infiltration