About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Thbs4tm1Olsa
targeted mutation 1, Olga Stenina-Adognravi
MGI:7628361
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Thbs4tm1Olsa/Thbs4tm1Olsa C57BL/6J-Thbs4tm1Olsa MGI:7628705
cx2
 		Apoetm1Unc/Apoetm1Unc
Thbs4tm1Olsa/Thbs4tm1Olsa 		involves: 129P2/OlaHsd * C57BL/6J MGI:7628726


Genotype
MGI:7628705
hm1
Allelic
Composition		 Thbs4tm1Olsa/Thbs4tm1Olsa
Genetic
Background		 C57BL/6J-Thbs4tm1Olsa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbs4tm1Olsa mutation (0 available); any Thbs4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:301049 )
N
• normal number of monocytes in blood after LPS-induced peritonitis
decreased macrophage cell number ( J:301049 )
• in peritoneal tissues after LPS-induced peritonitis
• reduced number of macrophages collected by peritoneal lavage after LPS-induced peritonitis

cardiovascular system
abnormal retina vasculature morphology ( J:301119 )
• more retinal vasculature at age P5 with more branchpoints

immune system
decreased macrophage cell number ( J:301049 )
• in peritoneal tissues after LPS-induced peritonitis
• reduced number of macrophages collected by peritoneal lavage after LPS-induced peritonitis

homeostasis/metabolism
enhanced wound healing ( J:301119 )
• significantly smaller wound 5 days post-wounding

vision/eye
abnormal retina vasculature morphology ( J:301119 )
• more retinal vasculature at age P5 with more branchpoints




Genotype
MGI:7628726
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Thbs4tm1Olsa/Thbs4tm1Olsa
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (162 available)
Thbs4tm1Olsa mutation (0 available); any Thbs4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased macrophage cell number ( J:345752 )
• in atherosclerotic lesions when fed western diet
• increased CD38+ pro-inflammatory macrophages in atherosclerotic lesions when fed western diet

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:345752 )
N
• normal plasma LDL/VLDL and HDL levels when fed either western diet or regular chow
increased cholesterol level ( J:345752 )
• increased free and total cholesterol levels when fed western diet
• normal when fed regular chow
increased chemokine level ( J:345752 )
• increased plasma CXCL1 and CCL2 levels when fed western diet

immune system
increased macrophage cell number ( J:345752 )
• in atherosclerotic lesions when fed western diet
• increased CD38+ pro-inflammatory macrophages in atherosclerotic lesions when fed western diet
increased chemokine level ( J:345752 )
• increased plasma CXCL1 and CCL2 levels when fed western diet




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory