Phenotypes associated with this allele

• Allele Symbol: Fmo1^em1Anz
• Allele Name: endonuclease-mediated mutation 1, Zhuoling An
• Allele ID: MGI:7628220
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fmo1^em1Anz/Fmo1^em1Anz	involves: C57BL/6N	MGI:7628222

Genotype
MGI:7628222

hm1

• Allelic Composition: Fmo1^em1Anz/Fmo1^em1Anz
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased dopaminergic neuron number ( J:312983 )

• the number of TH-positive neurons in the substantia nigra pars compacta is about 30% lower compared to wild-type controls

abnormal neuron physiology ( J:312983 )

• lower levels of Parkin protein

behavior/neurological

behavior/neurological phenotype ( J:312983 )

N • no defects in motor function are detected

homeostasis/metabolism

increased cytokine level ( J:312983 )

• increased levels of IL1B and IL6 in the substantia nigra and striatum

immune system

increased cytokine level ( J:312983 )

• increased levels of IL1B and IL6 in the substantia nigra and striatum