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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lig4em1(IMPC)Ccpcz
endonuclease-mediated mutation 1, Institute of Molecular Genetics
MGI:7627385
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lig4em1(IMPC)Ccpcz/Lig4em1(IMPC)Ccpcz C57BL/6NCrl-Lig4em1(IMPC)Ccpcz/Ph MGI:8298356
ht2
 		Lig4em1(IMPC)Ccpcz/Lig4+ C57BL/6NCrl-Lig4em1(IMPC)Ccpcz/Ph MGI:8176228


Genotype
MGI:8298356
hm1
Allelic
Composition		 Lig4em1(IMPC)Ccpcz/Lig4em1(IMPC)Ccpcz
Genetic
Background		 C57BL/6NCrl-Lig4em1(IMPC)Ccpcz/Ph
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4em1(IMPC)Ccpcz mutation (1 available); any Lig4 mutation (45 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo size ( J:211773 )
IMPC - CCP-IMG

growth/size/body
embryonic growth retardation ( J:211773 )
IMPC - CCP-IMG
abnormal embryo size ( J:211773 )
IMPC - CCP-IMG

mortality/aging




Genotype
MGI:8176228
ht2
Allelic
Composition		 Lig4em1(IMPC)Ccpcz/Lig4+
Genetic
Background		 C57BL/6NCrl-Lig4em1(IMPC)Ccpcz/Ph
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4em1(IMPC)Ccpcz mutation (1 available); any Lig4 mutation (45 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased heart weight ( J:211773 )
IMPC - CCP-IMG

endocrine/exocrine glands
enlarged thymus ( J:211773 )
IMPC - CCP-IMG

growth/size/body
increased kidney weight ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

hematopoietic system
enlarged thymus ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

immune system
enlarged thymus ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

renal/urinary system

reproductive system
enlarged uterus ( J:211773 )
IMPC - CCP-IMG

skeleton

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory