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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chapirem1Kwan
endonuclease-mediated mutation 1, Kun Wang
MGI:7627348
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chapirem1Kwan/Chapirem1Kwan involves: C57BL/6 MGI:7627350


Genotype
MGI:7627350
hm1
Allelic
Composition		 Chapirem1Kwan/Chapirem1Kwan
Genetic
Background		 involves: C57BL/6
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See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:310115 )
N
• no gross cardiac abnormalities under normal conditions
decreased response of heart to induced stress ( J:310115 )
• hypertrophic response to transverse aortic constriction (TAC) is blocked
• ventricle function is improved and fibrosis is reduced following TAC

homeostasis/metabolism
decreased response of heart to induced stress ( J:310115 )
• hypertrophic response to transverse aortic constriction (TAC) is blocked
• ventricle function is improved and fibrosis is reduced following TAC




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory