Phenotypes associated with this allele

• Allele Symbol: Ppp1r12b^em1Chana
• Allele Name: endonuclease-mediated mutation 1, Audrey N Chang
• Allele ID: MGI:7621836
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ppp1r12b^em1Chana/Ppp1r12b^em1Chana A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: C57BL/6J * FVB/N	MGI:7621837

Genotype
MGI:7621837

cn1

• Allelic Composition: Ppp1r12b^em1Chana/Ppp1r12b^em1Chana; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:346986 )

N • despite the increase in cardiac myosin regulatory light chain phosphorylation after tamoxifen treatment, no difference in heart size is detected

abnormal myocardial fiber morphology ( J:346986 )

• in tamoxifen treated mice the ratio of myosin in the SRX state to that in the DRX state is shifted with less in the SRX state compared to controls

decreased response of heart to induced stress ( J:346986 )

• tamoxifen treated mice show no cardiac hypertrophy in response to transaortic constriction induced pressure overload

• however, changes on protein expression induced by pressure overload in tamoxifen treated mice are similar to controls

muscle

abnormal myocardial fiber morphology ( J:346986 )

• in tamoxifen treated mice the ratio of myosin in the SRX state to that in the DRX state is shifted with less in the SRX state compared to controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:346986 )

• however, changes on protein expression induced by pressure overload in tamoxifen treated mice are similar to controls

• tamoxifen treated mice show no cardiac hypertrophy in response to transaortic constriction induced pressure overload